| Autor: |
Li, Yanlin, Liu, Jing, Zhao, Shuang, Du, Xuzhao, Guo, Minjie, Zhao, Wentao, Tang, Xiangyang, Wang, Guangwei |
| Zdroj: |
Organic Letters; 20240101, Issue: Preprints |
| Abstrakt: |
A general and facile synthetic method for β-fluoroenones from silyl enol ethers or ketones, with a copper–amine catalyst system, has been developed. The reaction proceeded by a tandem process of difluoroalkylation–hydrolysis–dehydrofluorination. This method is characterized by high yields, excellent Z/Eratios, a low-cost catalyst, and a broad substrate scope. The synthetic potential of β-fluoroenones has been demonstrated by the construction of various complicated organofluorine molecules. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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