Chromatographically homogeneous egg lecithin as stabilizer of emulsions for intravenous nutrition

Autor: Zeringue, H. J., Brown, M. L., Singleton, W. S.
Zdroj: Journal of the American Oil Chemists' Society; October 1964, Vol. 41 Issue: 10 p688-691, 4p
Abstrakt: Physically stable emulsions of cottonseed and soybean oils at 20% concn were prepared with chromatographically homogeneous egg lecithin at 1% concn as the sole emulsifier, and a 2.5% solution of glycerol as the aqueous phase. The physical stability of the emulsions was a function of the pH of the product, optimum pH 6.6~6.8. Aqueous solutions of dextrose and sorbitol decreased in pH to 4.8 when autoclaved, regardless of prior adjustment of pH to as high as 8.5, and emulsions in which these solutions were used as the aqueous phase exhibited phase separation. There was no significant decrease in pH, and no phase separation, in emulsions which contained glycerol solution as the aqueous phase. It appears that glycerol is superior to dextrose as the isotonic agent in lecithin-stabilized emulsions for intravenous nutrition. Particle sizes and their distribution in lecithin-stabilized emulsions of cottonseed and soybean oils were determined by means of a Coulter Counter. Approximately 99% of the oil in these emulsions was dispersed as particles whose diameters were no larger than 5 ?.
Databáze: Supplemental Index