| Autor: |
Kochneva-Pervukhova, Natalia V., Chechenova, Maria B., Valouev, Igor A., Kushnirov, Vitaly V., Smirnov, Vladimir N., Ter-Avanesyan, Michael D. |
| Zdroj: |
Yeast; April 2001, Vol. 18 Issue: 6 p489-497, 9p |
| Abstrakt: |
The yeast cytoplasmically-inherited nonsense suppressor [PSI+] determinant is presumed to be a manifestation of the aggregated prion-like state of the Sup35 protein. Overexpression of the Sup35 protein induces generation of [PSI+] determinants with various suppressor efficiency and mitotic stabilities. Here, we demonstrate that the relative frequency of appearance of [PSI+] with different properties depends on the SUP35 allele used to induce their generation. The difference in properties of [PSI+] determinants was preserved after their transmission from one yeast strain to another. This difference correlated with variation in properties of the Sup35 protein. A novel type of prion instability was observed: some [PSI+] with weak suppressor efficiency could convert spontaneously into strong suppressor determinants. Copyright © 2001 John Wiley & Sons, Ltd. |
| Databáze: |
Supplemental Index |
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