Addition of Dithiols to Bis-Ynones:  Development of a Versatile Platform for the Synthesis of Polyketide Natural Products

Autor: Sneddon, H. F., Gaunt, M. J., Ley, S. V.
Zdroj: Organic Letters; April 2003, Vol. 5 Issue: 7 p1147-1150, 4p
Abstrakt: The conjugate addition of dithiols to bis-ynones generates a versatile masked 1,3,5-triketone platform. These functional units are useful intermediates for the synthesis of oxygen-containing heterocycles commonly found in polyketide natural products. The tetrahydropyranyl fragments of the marine macrolides Lyngbouilloside and Callipeltoside A have been synthesized with use of this methodology.
Databáze: Supplemental Index