Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial

Autor: Itenov, Theis Skovsgaard, Johansen, Maria Egede, Bestle, Morten, Thormar, Katrin, Hein, Lars, Gyldensted, Louise, Lindhardt, Anne, Christensen, Henrik, Estrup, Stine, Pedersen, Henrik Planck, Harmon, Matthew, Soni, Uday Kant, Perez-Protto, Silvia, Wesche, Nicolai, Skram, Ulrik, Petersen, John Asger, Mohr, Thomas, Waldau, Tina, Poulsen, Lone Musaeus, Strange, Ditte, Juffermans, Nicole P, Sessler, Daniel I, Tønnesen, Else, Møller, Kirsten, Kristensen, Dennis Karsten, Cozzi-Lepri, Alessandro, Lundgren, Jens D, Jensen, Jens-Ulrik, Jensen, Jens-Ulrik Stæhr, Itenov, Theis Skovsgaard, Johansen, Maria Egede, Lundgren, Jens, Tønnesen, Else, Bestle, Morten, Lindhardt, Anne, Christensen, Henrik, Planck Pedersen, Henrik, Poulsen, Lone Musaeus, Cozzi-Lepri, Alessandro, Illkjær, Susanne, Soni, Uday Kant, Møller, Kirsten, Juffermans, Nicole P, Sessler, Daniel I, Mohr, Thomas, Masur, Henry, Torp-Pedersen, Christian, Copas, Andrew, Nielsen, Birgit Riis, Kristensen, Dennis Karsten, Grarup, Jesper, Hansen, Jette, Nielsen, Kim, Valbjørn, Lone, Lauritzen, Sanne, Kold, Tina, Grundahl, Kathrine, Hein, Lars, Rasmussen, Rikke Hein, Wesche, Nikolaj, Blom, Hasse, Jensen, Peer Eske, Galle, Tina, Thaarslund, Bente, Skandov, Camilla, Langholz, Iben, Skram, Ulrik, Berthelsen, Rasmus Ehrenfried, Kjær, Dorthe, Uldbjerg, Merete, Lipsius, Lily, Gyldensted, Louise, Engsig, Magaly, Helsted, Rikke, Andersen, Birgitte, Nygaard, Eigil, Strande, Søren, Bangash, Aimal Khan, Waldau, Tina, Søe-Jensen, Peter, Tousi, Hamid, Tangager, Malene, Hagi-Pedersen, Daniel, Gatz, Rainer Karl-Heinz, Engen, Marte Kaasen, Wamberg, Christian Åge, Westergaard, Bo, Harmon, Matthew, Thormar, Katrin, Stoktoft, Stine, Scherwin, Rebecca, Bærentzen, Finn, Lauritzen, Marlene, Pott, Frank, Bruun, Christina, Meyhoff, Christian, Strange, Ditte Gry, Palmqvist, Dorthe Fris, Hemmingsen, Claus, Gärtner, Rune, Petersen, John Asger, Jung, Kai Dieter, La Porte, Louise, Viuf, Mette, Troglauer, Johannes, Borovnjak, Silva, Strandkjær, Nina, Bretlau, Claus, Hansen, Marianna, Zaulich, Lea Kielsgaard, Overgaard, Christian, Bergenholtz, Katja, Jansen, Tejs, Bæk-Jensen, Mette Astrup, Detlefsen, Monika, Albrechtsen, Tannie Lund, Sode, Birgitte Margareta, Boesen, Hans Christian, Thostrup, Maria, Estrup, Stine, Andersen, Torben Mogens, Kjelsteen, Katrine, Winther Kjær, Cilia Klara, Haunstrup, Elsebeth, Christensen, Ole, Spliid, Lone, Rasmussen, Birgitte, Jejlskov, Henriette, Borchorst, Søren, Abdel-Wahab, Akil Walli Raad, Brysting, Marianne, Victor, Jette, Stensbirk, Anette, Bjerregaard, Karen, Poulsen, Anne, Roed, Annette Brix, Bech, Bianca, Perez-Protto, Silvia, Yilmaz, Oguz, Ahuja, Sanchit, Suleiman, Iman, Iglesias, Rodrigo, Breum, Olena
Zdroj: The Lancet Respiratory Medicine; March 2018, Vol. 6 Issue: 3 p183-192, 10p
Abstrakt: Animal models of serious infection suggest that 24 h of induced hypothermia improves circulatory and respiratory function and reduces mortality. We tested the hypothesis that a reduction of core temperature to 32–34°C attenuates organ dysfunction and reduces mortality in ventilator-dependent patients with septic shock.
Databáze: Supplemental Index