| Autor: |
Ghezzi, Pietro, Erroi, Annalaura, Acero, Raffaella, Salmona, Mario, Mantovani, Alberto |
| Zdroj: |
Journal of Leukocyte Biology; July 1987, Vol. 42 Issue: 1 p84-90, 7p |
| Abstrakt: |
Macrophages were isolated from poorly immunogenic metastatic sarcomas (mFS6 and MN/MCA1) of C57BL/6 origin. Tumor‐associated macrophages (TAM) showed little release of superoxide when exposed to phorbol myristate acetate. When exposed to a phagocytic stimulus (zymosan), TAM released appreciable amounts of superoxide. TAM had a lower number of specific binding sites for phorbol esters than resident or caseinate‐elicited peritoneal macrophages, but had normal NADPH‐cytochrome C reductase. The tumor environment, possibly through previously demonstrated products of neoplastic cells, may influence the functional status of in situ macrophages and, thus, impair host anti‐tumor and anti‐microbial defense mechanisms. |
| Databáze: |
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