Establishment of the role of IL‐6 and TNF receptor 1 using gene knockout mice

Autor: Bluethmann, Horst, Rothe, Joachim, Schultze, Nathalie, Tkachuk, Maria, Koebel, Pascale
Zdroj: Journal of Leukocyte Biology; November 1994, Vol. 56 Issue: 5 p565-570, 6p
Abstrakt: Cytokines are known to be key players in host response to infection, immunological disorders, and tissue injury in the attempt of an organism to overcome the insult and restore homeostasis. Another important aspect of cytokines, however, is their normal physiological role during development in the unchallenged organism. The most elegant way to analyze both of these functions is to introduce targeted mutations in embryonic stem cells in order to create new mouse strains deficient for a given cytokine and identify the functions that are consequently impaired or lost, This review summarizes the mutant phenotypes of mice carrying a null mutation in the cytokine IL‐6gene or the tumor necrosis factor receptor 1 (Tnfr1) gene. Results for interferon– and interferon‐γreceptor‐deficient mice are included for comparison. J. Leukoc. Biol.56: 565–570; 1994.
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