| Autor: |
Chapes, Stephen K., Morrison, Dennis R., Guikema, James A., Lewis, Marian L., Spooner, Brian S. |
| Zdroj: |
Journal of Leukocyte Biology; July 1992, Vol. 52 Issue: 1 p104-110, 7p |
| Abstrakt: |
Cultured, bone marrow–derived macrophages, murine spleen and lymph node cells, and human lymphocytes were tested for their ability to secrete cytokines in space. Lipopolysaccharide‐activated bone marrow macrophages were found to secrete significantly more interleukin‐1 and tumor necrosis factor when stimulated in space than when stimulated on earth. Murine spleen cells stimulated with poly I:C in space released significantly more interferon‐α at 1 and 14 hours after stimulation than cells stimulated on earth. Similarly, murine lymph node T cells and human peripheral blood lymphocytes, stimulated with concanavalin A in space, secreted significantly more interferon‐γ than ground controls. These data suggest that space flight has a significant enhancing effect on immune cell release of cytokines in vitro. |
| Databáze: |
Supplemental Index |
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