| Autor: |
Roebuck, Kenneth A., Carpenter, Laura R., Lakshminarayanan, Venkatesh, Page, Scott M., Moy, James N., Thomas, Larry L. |
| Zdroj: |
Journal of Leukocyte Biology; March 1999, Vol. 65 Issue: 3 p291-298, 8p |
| Abstrakt: |
The promoters of the IL‐8, MCP‐1, and RANTES genes contain binding sites for the redox‐responsive transcription factors AP‐1 and NF‐κB, which have been shown to be important for their expression. In this overview, we present evidence from our laboratories that the stimulus‐specific regulation of these chemokines by the reactive oxidant H2O2, the proinflammatory cytokine TNF‐α, and respiratory syncytial virus (RSV) is mediated in a cell type‐specific manner involving different patterns of AP‐1 and NF‐κB binding activity. Our results demonstrate that H2O2induction of IL‐8 gene expression is linked with the selective binding of AP‐1 to the IL‐8 promoter, whereas TNF‐α and RSV induction of IL‐8 correlates with the activation of NF‐κB binding. We propose that the differential activation and binding of inducible transcription factors to the promoter regions of chemokine genes provides a critical regulatory mechanism by which the CXC and CC chemokines can be selectively expressed in a cell type‐specific and stimulus‐specific manner. Such a regulatory mechanism of differential chemokine expression could critically influence the site‐ specific recruitment of distinct subsets of leukocytes to sites of inflammation and injury. J. Leukoc. Biol.65: 291–298; 1999. |
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