| Autor: |
Church, Dawson, Yount, Garret, Rachlin, Kenneth, Fox, Louis, Nelms, Jerrod |
| Zdroj: |
American Journal of Health Promotion; January 2018, Vol. 32 Issue: 1 p112-122, 11p |
| Abstrakt: |
Purpose: To assess the feasibility of measuring changes in gene expression associated with post-traumatic stress disorder (PTSD) treatment using emotional freedom techniques (EFT).Design: Participants were randomized into an EFT group receiving EFT and treatment as usual (TAU) throughout a 10-week intervention period and a group receiving only TAU during the intervention period and then receiving EFT.Setting: A community clinic and a research institute in California.Participants: Sixteen veterans with clinical levels of PTSD symptoms.Intervention: Ten hour-long sessions of EFT.Measures: Messenger RNA levels for a focused panel of 93 genes related to PTSD. The Symptom Assessment 45 questionnaire, Hospital Anxiety and Depression Scale, Insomnia Severity Scale, SF-12v2 for physical impairments, and Rivermead Postconcussion Symptoms Questionnaire.Analysis: Pre-, posttreatment, and follow-up mean scores on questionnaires were assessed using repeated measures 1-way analysis of variance. A Student ttest and post hoc analyses were performed on gene expression data.Results: Post-traumatic stress disorder symptoms declined significantly in the EFT group (−53%, P< .0001). Participants maintained their gains on follow-up. Significant differential expression of 6 genes was found (P< .05) when comparing the expression levels before and after the intervention period in participants receiving EFT.Conclusion: Study results identify candidate gene expression correlates of successful PTSD treatment, providing guidelines for the design of further studies aimed at exploring the epigenetic effects of EFT. |
| Databáze: |
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