| Autor: |
Noel, Georges, Habrand, Jean-Louis, Helfre, Sylvie, Mammar, Hamid, Kalifa, Chantal, Ferrand, Régis, Beaudre, Anne, Gaboriaud, Geneviève |
| Zdroj: |
Medical and Pediatric Oncology; May 2003, Vol. 40 Issue: 5 p309-315, 7p |
| Abstrakt: |
The purpose of the study was to evaluate clinical results and complications of a combination of proton and photon irradiation administered to 17 children with selected central nervous system (CNS) tumors. Between July 1994 and September 2000, 17 children, aged from 5 to 17 years (median: 12 years) with intracranial benign (6 cases) or malignant (11 cases) tumors, were treated with photons (median dose: 40 Gy; 2454) and protons (median dose: 20 CGE; 931) at the Centre de Protonthérapie d'Orsay (CPO). Mean follow-up was 27 months (381). Two patients recurred locally (one marginal and one in situ). Fifteen patients are alive and doing well. Overall, 12, 24, and 36-month local control rate was 92 ± 8% and, 12, 24, and 36-month overall survival rates were 93 ± 6%, 83 ± 11%, and 83 ± 11%, respectively. Clinical initial symptoms remained stable or subsided in all patients. Early toxicities were in the expected range. With a mean 27 months follow-up, protontherapy was well tolerated for doses upto 69 CGE and with an excellent local control rate. Med Pediatr Oncol 2003;40:309315. © 2003 Wiley-Liss, Inc. |
| Databáze: |
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