| Autor: |
Loos, Bruno G., Roos, Marijke T.L., Schellekens, Peter Th.A., Velden, Ubele van der, Miedema, Frank |
| Zdroj: |
Journal of Periodontology; April 2004, Vol. 75 Issue: 4 p557-564, 8p |
| Abstrakt: |
Background:T and B lymphocytes play important roles in periodontitis. Smoking is considered a risk factor for periodontitis and may exert its negative effects through leukocytes. Taking smoking into consideration, the aim of this study was to analyze numbers of circulating T (CD3+) cells and their CD4+and CD8+subpopulations, B (CD19+) cells, and T‐cell proliferative capacity in periodontitis. Methods:Lymphocyte immunophenotyping for T cells, their CD4+and CD8+subsets, and B cells was performed on peripheral blood from 76 periodontitis patients and 36 controls. Proliferative capacity of T cells was determined in whole‐blood lymphocyte culture assays after mitogenic stimulation. Results:Total T cells, CD4+and CD8+subpopulations, and responsiveness to specific T‐cell stimuli did not differ between patients and controls; in addition, B cells were not significantly elevated in periodontitis patients. However, more periodontal breakdown in smoking patients was associated with higher numbers of CD3+T cells, as well as with CD4+and CD8+T‐cell subsets, and increased T‐cell proliferation. Numbers of B cells were not affected by smoking. Conclusions:The increased numbers of T‐cells and elevated T‐cell responsiveness in patients who smoke may be one of several explanations why smoking is a risk factor for periodontitis. The mechanism of how T‐cell function contributes to increase the severity of periodontal breakdown in smoking periodontitis patients needs to be investigated further. J Periodontol 2004;75:557‐564. |
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