| Autor: |
Aleo, Joseph J. |
| Zdroj: |
Journal of Periodontology; May 1981, Vol. 52 Issue: 5 p251-254, 4p |
| Abstrakt: |
An hypothesisis proposed relating the possible role of vitamin C deficiency as an etiologic factor contributing to periodontal disease in diabetes. The hypothesis is based upon the following: (1) transport of ascorbate across cell membranes may be impaired by glucose, but facilitated by insulin; (2) glucose utilization is significantly accelerated by sublethal concentrations of endotoxin; (3) endotoxin‐induced histamine sensitivity of tissue is enhanced by ascorbic deficiency; and (4) ascorbic acid deficiency alters mucosal barrier function. The interrelationship of these factors is discussed. |
| Databáze: |
Supplemental Index |
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