Zinc-Ligand Swapping Mediated Complex Formation and Sulfur Transfer between SufS and SufU for Iron–Sulfur Cluster Biogenesis in Bacillus subtilis

Autor: Fujishiro, Takashi, Terahata, Takuya, Kunichika, Kouhei, Yokoyama, Nao, Maruyama, Chihiro, Asai, Kei, Takahashi, Yasuhiro
Zdroj: Journal of the American Chemical Society; 20240101, Issue: Preprints
Abstrakt: SufU is a zinc-containing protein involved in mobilization of sulfur from SufS for iron–sulfur cluster biogenesis of Bacillus subtilis. Structural basis for the sulfur transfer in SufS–SufU complex was revealed. A zinc-ligand exchange reaction upon SufS–SufU complexation provides a free thiol from Cys41 of SufU as a sulfur acceptor.
Databáze: Supplemental Index