NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Autor:	Alvarez, Samantha W., Sviderskiy, Vladislav O., Terzi, Erdem M., Papagiannakopoulos, Thales, Moreira, Andre L., Adams, Sylvia, Sabatini, David M., Birsoy, Kıvanç, Possemato, Richard
Zdroj:	Nature; November 2017, Vol. 551 Issue: 7682 p639-643, 5p
Abstrakt:	Cancers growing in high-oxygen environments, such as lung adenocarcinomas, select for the iron–sulfur cluster synthesizing enzyme NFS1 to support malignant proliferation and to protect from oxidative damage.
Databáze:	Supplemental Index
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