Synthesis of Nodulisporic Acid 2‘ ‘-Oxazoles and 2‘ ‘-Thiazoles

Autor: Berger, R., Shoop, W. L., Pivnichny, J. V., Warmke, L. M., Zakson-Aiken, M., Owens, K. A., deMontigny, P., Schmatz, D. M., Wyvratt, M. J., Fisher, M. H., Meinke, P. T., Colletti, S. L.
Zdroj: Organic Letters; November 2001, Vol. 3 Issue: 23 p3715-3718, 4p
Abstrakt: The semisynthetic conversion of nodulisporic acid A (1) into a set of three heterocyclic side chain derivatives provided compounds, highlighted by 6, with an improved spectrum of ectoparasiticidal activity and pharmacokinetic profile relative to the natural product.
Databáze: Supplemental Index