| Autor: |
Nakatani, Yoshio, Opel-Reading, Helen K., Merker, Matthias, Machado, Diana, Andres, Sönke, Kumar, S. Siva, Moradigaravand, Danesh, Coll, Francesc, Perdigão, João, Portugal, Isabel, Schön, Thomas, Nair, Dina, Devi, K. R. Uma, Kohl, Thomas A., Beckert, Patrick, Clark, Taane G., Maphalala, Gugu, Khumalo, Derrick, Diel, Roland, Klaos, Kadri, Aung, Htin Lin, Cook, Gregory M., Parkhill, Julian, Peacock, Sharon J., Swaminathan, Soumya, Viveiros, Miguel, Niemann, Stefan, Krause, Kurt L., Köser, Claudio U. |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; October 2017, Vol. 61 Issue: 12 |
| Abstrakt: |
ABSTRACTA screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosisrevealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitroMIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to d-cycloserine. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
