Mild and Efficient Copper-Catalyzed Amination of Aryl Bromides with Primary Alkylamines

Autor: Kwong, F. Y., Buchwald, S. L.
Zdroj: Organic Letters; March 2003, Vol. 5 Issue: 6 p793-796, 4p
Abstrakt: An efficient copper-catalyzed amination of aryl bromides with primary alkylamines was developed that uses commercially available diethylsalicylamide as the ligand. This amination reaction can be performed at 90 °C in good yield. A variety of functional groups are compatible with these reaction conditions. Preliminary results show that this reaction can be carried out under solvent-free conditions with comparable yields.
Databáze: Supplemental Index