Molecular detection of multidrug-resistant Mycobacterium lepraefrom Indian leprosy patients

Autor: Lavania, Mallika, Singh, Itu, Turankar, Ravindra P., Ahuja, Madhvi, Pathak, Vinay, Sengupta, Utpal, Das, Loretta, Kumar, Archana, Darlong, Joydeepa, Nathan, Rajeev, Maseey, Asha
Zdroj: Journal of Global Antimicrobial Resistance; March 2018, Vol. 12 Issue: 1 p214-219, 6p
Abstrakt: •Detection of multidrug-resistant Mycobacterium lepraefrom relapse leprosy patients from endemic regions in India.•Resistance profiles of strains to rifampicin, dapsone and ofloxacin were determined.•Resistance confirmed by identification of mutations in genes earlier shown to be associated with resistance to each drug.•Fifteen strains showed representative mutations in at least two drug resistance genes.•Two strains showed mutations in all three genes responsible for resistance to rifampicin, dapsone and ofloxacin.
Databáze: Supplemental Index