| Autor: |
Higaki, Yuko, Mizushima, Junichi, Kawashima, Makoto, Motoji, Toshiko, Mizoguchi, Hideaki |
| Zdroj: |
Dermatology; 2003, Vol. 206 Issue: 2 p157-160, 4p |
| Abstrakt: |
AbstractA 59-year-old Japanese woman showed recurrent violaceous, indurated erythemas and papules on the buttocks and extremities for a period of 7 years. The lesions showed histologically epithelioid cell granulomas associated with lymphocytes. After 7 years, the patient developed adult T-cell leukemia (ATL), of the acute type, the course of which was fatal. Immunohistochemical staining of the skin sections of granulomatous lesions showed prominent infiltration of CD25-positive cells. Human T-lymphotropic virus type I proviral DNA and monoclonal T-cell receptor β gene rearrangement were detected in the skin samples by a retrospectively performed gene analysis. We believe that the patient initially had an unusual cutaneous type of ATL in which granulomas occurred as a host-protective response against ATL progression.Copyright © 2003 S. Karger AG, Basel |
| Databáze: |
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