| Autor: |
Feng, Ruokun, Ning, Hanqi, Su, Han, Gao, Yuan, Yin, Haotian, Wang, Yudan, Yang, Zhen, Qi, Chenze |
| Zdroj: |
The Journal of Organic Chemistry; 20240101, Issue: Preprints |
| Abstrakt: |
Described herein is a convenient and highly selective synthesis of alkynylated isoquinolines and biisoquinolines from various aryl ketone O-pivaloyloxime derivatives and 1,3-diynes via rhodium-catalyzed C–H bond activation. In this transformations, alkynylated isoquinolines, 3,4′- and 3,3′-biisoquinolines could be obtained respectively through changing the reaction conditions. Mechanistic investigation revealed that the C–H activation of aryl ketone O-pivaloyloxime was the key step to this reaction. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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