Mixed acetals of cyclodextrins. Preparation of hexakis-, heptakis- and octakis[2,6-di- O -(methoxydimethyl)methyl]-α-, β- and γ-cyclodextrins

Autor: Lipta´k, Andra´s, Ja´nossy, Lo´ra´nt, Borba´s, Aniko´, Szejtli, Jo´zsef
Zdroj: Carbohydrate Research; 2002, Vol. 337 Issue: 2 p93-96, 4p
Abstrakt: The proton-catalyzed addition of 2-methoxypropene to α-, β- and γ-cyclodextrins resulted in hexakis-, heptakis-, and octakis[2,6-di -O- (methoxydimethyl)methyl]-α-, β- and γ-cyclodextrins, but no reaction was observed of CD-s with 2,2-dimethoxypropane. The mixed acetal-type compounds can be alkylated under basic conditions. The preparation of hexakis(3 -O- benzyl)-α-cyclodextrin demonstrates the synthetic value of this methodology.
Databáze: Supplemental Index
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