| Autor: |
Wakade, Sandip Balasaheb, Tiwari, Dipak Kumar, Ganesh, Pothapragada S. K. Prabhakar, Phanindrudu, Mandalaparthi, Likhar, Pravin R., Tiwari, Dharmendra Kumar |
| Zdroj: |
Organic Letters; 20240101, Issue: Preprints |
| Abstrakt: |
A transition-metal-free method for the construction of functionalized quinolines from readily available acetophenones and anthranils is reported. This one-pot reaction cascade involves in situ generation of α,β-unsaturated ketones from the acetophenone via one-carbon homologation by DMSO followed by the aza-Michael addition of anthranils and subsequent annulation. DMSO acted in this reaction not only as solvent but also as one carbon source, thus providing a highly atom-economical and environmentally benign approach for the synthesis of 3-substituted quinolines. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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