| Autor: |
Vishwanatha, Thimmalapura M., Kurpiewska, Katarzyna, Kalinowska-Tłuścik, Justyna, Dömling, Alexander |
| Zdroj: |
The Journal of Organic Chemistry; 20240101, Issue: Preprints |
| Abstrakt: |
An alternative approach toward the simple and robust synthesis of highly substituted peptidic thiazole derivatives using Ugi-multicomponent reaction (U-MCR) is described. Thus, we introduced the enantiopure (R)-2-methyl-2-isocyano-3-(tritylthio)propanoate as a novel class of isocyanide in MCR. This bifunctional isocyanide was found to undergo mild cyclodehydration to afford thiazole containing peptidomimetics in a short synthetic sequence. Several examples of bis-heterocyclic rings were also synthesized through the proper choice of the aldehyde component in the U-4CR. The method opens a wide range of applications toward the synthesis of nonribosomal natural products and other bioactive compounds. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
