| Autor: |
Barlows, Theodore G., Luque, Carla A., Bernstein-Solomon, Bridget J., Menendez, Lourdes B. |
| Zdroj: |
Hospital Pharmacy; March 2004, Vol. 39 Issue: 3 p238-242, 5p |
| Abstrakt: |
Purpose This study evaluated the incidence of nephrotoxicity due to once daily aminoglycoside (ODA) use in elderly patients at two South Florida institutions.Methods A retrospective review of all patients who received 7 mg/kg/day of either gentamicin or tobramycin was conducted.Results Eighty-one (49%) males and 84 (51%) females with a mean age of 73 (range, 60 to 95) years were included. Nephrotoxicity was evident in 16 patients (9.7%). Of these, eight (4.8%) experienced nephrotoxicity possibly associated with aminoglycoside administration. A subgroup analysis of nonnephrotoxic patients compared with nephrotoxic patients revealed no significant differences in mean initial serum creatinine (1 mg/dL vs 0.95 mg/dL, P = 0.861) or dosing interval (31.4 vs 31.5 hours, P = 0.983). The mean duration of aminoglycoside treatment was less in the nonnephrotoxic group compared with the nephrotoxic group (5.2 vs 9.9 days, P < 0.05).Conclusion The results of this retrospective evaluation suggest that ODA dosing in the elderly is safe; however, patients should be monitored closely, especially when they require more than 5 days of aminoglycoside therapy, or are receiving concomitant nephrotoxic agents. |
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