Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial

Autor: Sivaprasad, Sobha, Prevost, A Toby, Vasconcelos, Joana C, Riddell, Amy, Murphy, Caroline, Kelly, Joanna, Bainbridge, James, Tudor-Edwards, Rhiannon, Hopkins, David, Hykin, Philip, Bhatnagar, A, Burton, B, Chakravarthy, U, Eleftheriadis, H, Empeslidis, T, Gale, R, George, S, Habib, M, Kelly, S, Lotery, A, McKibbin, M, Membrey, L, Menon, G, Mushtaq, B, Nicholson, L, Ramu, J, Osoba, O, Patel, J, Prakash, P, Purbrick, R, Ross, A, Stylianides, A, Talks, J, Chakravarthy, U, Harding, S, Peto, T, Yeo, S T, Laidlaw, Alistair, Amoaku, Winfried, Hood, Gillian, Hitman, Graham A, Preece, Daniel, Burns, Paul, Walker, Sarah, Mensah, Evelyn, Karia, Niral
Zdroj: The Lancet; June 2017, Vol. 389 Issue: 10085 p2193-2203, 11p
Abstrakt: Proliferative diabetic retinopathy is the most common cause of severe sight impairment in people with diabetes. Proliferative diabetic retinopathy has been managed by panretinal laser photocoagulation (PRP) for the past 40 years. We report the 1 year safety and efficacy of intravitreal aflibercept.
Databáze: Supplemental Index