| Autor: |
Mulder, Jason A., Gao, Joe, Fandrick, Keith R., Zeng, Xingzhong, Desrosiers, Jean-Nicolas, Patel, Nitinchandra D., Li, Zhibin, Rodriguez, Sonia, Lorenz, Jon C., Wang, Jun, Ma, Shengli, Fandrick, Daniel R., Grinberg, Nelu, Lee, Heewon, Bosanac, Todd, Takahashi, Hidenori, Chen, Zhidong, Bartolozzi, Alessandra, Nemoto, Peter, Busacca, Carl A., Song, Jinhua J., Yee, Nathan K., Mahaney, Paige E., Senanayake, Chris H. |
| Zdroj: |
Organic Process Research & Development; 20240101, Issue: Preprints |
| Abstrakt: |
A practical and efficient synthesis of the FLAP inhibitor 1was developed addressing multiple scale-up and safety concerns posed by the established synthesis and utilized a resolution strategy (replacing supercritical fluid chromatography (SFC) separation) for expedient access to the key structural component of 1: the challenging chiral quaternary center. Also highlighted are in situ IR monitoring, condensation to form the 1,2,4-oxadiazole ring, and an efficient Suzuki-Miyaura coupling. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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