PULMONARY LESIONS ASSOCIATED WITH BLEOMYCIN THERAPY IN MALIGNANCIES

Autor: BHARDWAJ, JR, KARTIK, K, SAMBANDAM, S
Zdroj: Medical Journal Armed Forces India; July 1994, Vol. 50 Issue: 3 p167-170, 4p
Abstrakt: Pulmonary lesions in seven patients with malignancy who were treated with bleomycin were studied at autopsy. Six of them had symptoms of respiratory distress. The lesions showed a predilection for the lower lobe and subpleural zones. Diffuse alveolar damage progressing to interstitial pneumonitis at varying stages of evolution was observed in all cases. The changes included intra-alveolar proteinaceous exudate, extensive interstitial fibrosis and frank epithelial dysplasia simulating metastatic nodules.
Databáze: Supplemental Index