| Autor: |
Van De Kerkhove, Maarten-Paul, Di Florio, Ernesto, Scuderi, Vincenzo, Mancini, Antonio, Belli, Antonello, Bracco, Adele, Scala, Daniela, Scala, Simona, Zeuli, Laura, Di Nicuolo, Giuseppe, Amoroso, Pietro, Calise, Fulvio, Chamuleau, Robert A. F. M. |
| Zdroj: |
Cell Transplantation; September 2003, Vol. 12 Issue: 6 p563-568, 6p |
| Abstrakt: |
Recently a phase I clinical trial has been started in Italy to bridge patients with acute liver failure (ALF) to orthotopic liver transplantation (OLT) by the AMC-bioartificial liver (AMC-BAL). The AMC-BAL is charged with 10 × 109 viable primary porcine hepatocytes isolated from a specified pathogen-free (SPF) pig. Here we report a patient with ALF due to acute HBV infection. This patient was treated for 35 h by two AMC-BAL treatments and was bridged to OLT. There was improvement of biochemical and clinical parameters during the treatment. No severe adverse events were observed during treatment and follow-up of 15 months after hospital discharge. Possible porcine endogenous retrovirus (PERV) activity could not be detected in the patient's blood or blood cells up to 12 months after treatment. |
| Databáze: |
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