A New Approach to the Rapid Parallel Development of Four Neurokinin Antagonists. Part 3. Assembly of Neurokinin Antagonists

Autor: Parker, J. S., Bowden, S. A., Firkin, C. R., Moseley, J. D., Murray, P. M., Welham, M. J., Wisedale, R., Young, M. J., Moss, W. O.
Zdroj: Organic Process Research & Development; January 2003, Vol. 7 Issue: 1 p67-73, 7p
Abstrakt: Four neurokinin antagonists were assembled using a rapid parallel development approach. Research Department processes were scaled up if process safety and robustness were not compromised. Using this approach, 1 kg of each compound was rapidly delivered for clinical trials.
Databáze: Supplemental Index