| Autor: |
Manfredini, F, Rigolin, GM, Malagoni, AM, Catizone, L, Mandini, S, Sofritti, O, Mauro, E, Soffritti, S, Boari, B, Cuneo, A, Zamboni, P, Manfredini, R |
| Zdroj: |
Journal of International Medical Research; March 2009, Vol. 37 Issue: 2 p534-540, 7p |
| Abstrakt: |
Haemodialysis patients have few endothelial progenitor cells (EPCs) and an unfavourable cardiovascular outcome. The effects on peripheral blood CD34+cells and EPCs of a 6-month walking exercise programme were studied. Thirty dialysis patients (20 males, age 67 ± 12 years) were prescribed exercise (two daily 10-min home walking sessions at moderate intensity, group E, n= 16) or not prescribed exercise (control, group C, n= 14). On entry and after 6 months peripheral blood CD34+cells, EPCs (assessed as CD34+cells co-expressing AC133 and vascular endothelial growth factor receptor 2 [VEGFR2], and as endothelial colony-forming units [e-CFU]) and exercise capacity (6-min walking distance, 6MWD) were evaluated. In group E, 6MWD and e-CFU increased significantly during the study period, with no significant changes in CD34+or CD34+AC133+VEGFR2+cell numbers. The change in e-CFU was directly and significantly correlated to patient-reported training load. Group C showed no significant change in any variable. In haemodialysis patients, moderate-intensity exercise selectively increased the number of e-CFU. |
| Databáze: |
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