| Autor: |
Tidd, M J, Collins, W T, Chamberlain, J |
| Zdroj: |
Journal of International Medical Research; March 1976, Vol. 4 Issue: 2 p86-95, 10p |
| Abstrakt: |
The bioavailabilities of three spironolactone tablet formulations specially selected for major differences inin vitro dissolution tests were compared in normal male volunteers by measuring plasma and urinary levels of the pharmacologically active spironolactone metabolite canrenone. It was possible to demonstrate small but statistically significant differences in plasma canrenone concentration-time curves derived from the three formulations together with significant differences in the time course of urinary canrenone excretion. The bioavailabilities of the three formulations did not differ significantly although the tablet with the poorestin vitro dissolution produced a significantly delayed peak canrenone concentration.The dissolution rate methodology and results are described and an approach to the development of improvedin vitro dissolution tests for spironolactone is suggested.The use of a new method for canrenone estimation resulted in the incidental detection of two other quantitatively significant spironolactone metabolites and preliminary information is given on these. |
| Databáze: |
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