| Autor: |
Cumberland, N S, Roberts, J St Clair, Arnold, W S G, Patel, R K, Bowker, C H |
| Zdroj: |
Journal of International Medical Research; June 1992, Vol. 20 Issue: 3 p247-253, 7p |
| Abstrakt: |
A typhoid vaccine derived from the purified Vi capsular polysaccharide (CPS) antigen of Salmonella typhiwas compared with a heat-killed whole-cell typhoid vaccine in 637 healthy male volunteers. The individuals were placed in three groups: group 1 received two doses of heat-killed whole-cell typhoid vaccine, at an interval of 28 days; group 2 received a single dose of typhoid Vi CPS vaccine followed after 28 days by water for injection; and group 3 received water for injection on the first occasion and a single dose of typhoid Vi CPS vaccine 28 days later. Local and systemic adverse reactions were recorded for 5 days following each injection. Subjects receiving the typhoid Vi CPS vaccine complained of fewer local adverse reactions on each of the first 3 days following immunization: on day 1, 18.6% of subjects given typhoid Vi CPS vaccine reported local reactions compared with 59.7% of those receiving heat-killed whole-cell vaccine (P <0.001). The percentage of subjects receiving the heat-killed whole-cell vaccine who complained of systemic reactions was more than twice that of subjects receiving the Vi CPS vaccine (7.9% and 3.4%, respectively, on day 1; P< 0.01). |
| Databáze: |
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