| Autor: |
Hosoi, Junichi, Tsuchiya, Toru, Denda, Mitsuhiro, Ashida, Yutaka, Takashima, Akira, Granstein, Richard D., Koyama, Junichi |
| Zdroj: |
Journal of Cutaneous Medicine and Surgery; October 1998, Vol. 3 Issue: 2 p79-84, 6p |
| Abstrakt: |
Background: Stress is thought to exacerbate a number of diseases, some of which are skin disorders. Epidermal Langerhans' cells play a major role in cutaneous immune reactions.Objective: The effects of two types of stress on the cutaneous immune system were to be assessed in mice.Methods: Mice received stress by immobilization or housing at various population densities. Epidermal sheets were stained for I-A molecules (a member of class II major histocompatibility complex) and analyzed with a confocal-laser-scanning microscope. Contact hypersensitivity reaction to 2,4,6-trinitrochlorobenzene was elicited in mouse ears.Results: The cell density, intensity of I-A expression, and number of dendrites were decreased as the population density increased. Elicitation of contact hypersensitivity was suppressed in mice that received either population or immobilization stress. Increased I-A expression and number of dendrites were observed in adrenalectomized compared to sham-operated mice. The population-dependent suppression of contact hypersensitivity reaction was not observed in adrenalectomized mice. After incubation with serum from mice that received either immobilization stress or population stress, the expression of I-A molecules on a XS52 Langerhans' cell-like cell line was reduced.Conclusion: Stress affected the cutaneous immune system. There were indications that adrenergic hormones played a role in the regulation of the system. |
| Databáze: |
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