| Autor: |
Ishibashi, Nobuyasu, Kuwamura, Tsuneo, Sano, Hiromi, Yamamoto, Fumihiko, Haradahira, Terushi, Suzuki, Kazutoshi, Suhara, Tetsuya, Sasaki, Shigeki, Maeda, Minoru |
| Zdroj: |
Journal of Labelled Compounds and Radiopharmaceuticals; 30 March 2000, Vol. 43 Issue: 4 p375-383, 9p |
| Abstrakt: |
Derivatives of 9,10-ethanobenzo[b]quinolizinium are potent antagonists for the TCP-site of the NMDA receptor. Two fluoroethyl-substituted analogues were labelled with fluorine-18 by displacement of the tosylate with [18F]fluoride, followed by a Diels-Alder reaction. A methoxy-substituted analogue labelled with carbon-11 was obtained by O-methylation of the corresponding hydroxy precursor with [11C]iodomethane. In biodistribution studies in mice with these three radioligands, it was found that they have little ability to penetrate the blood-brain barrier. Copyright © 2000 John Wiley & Sons, Ltd. |
| Databáze: |
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