Model for Korsakoff-Type Amnesias: Negative Effects from the Amygdala and Mamillary Body

Autor: Poschel, B. P. H., Ninteman, F. W.
Zdroj: Psychological Reports; December 1978, Vol. 43 Issue: 3 p767-770, 4p
Abstrakt: Intracranial electrodes were implanted bilaterally in the anterior area of the amygdala (n= 7), or unilaterally in the mamillary body (n= 6) of Hot: (SD) male rats. The rats were then trained to run back and forth to obtain food pellets at either end of a runway. At the midpoint were two adjacent doorways. Passing through the correct doorway set up food-pellet delivery. Passing through the incorrect doorway merely registered as an error. Daily test sessions lasted 25 min., and accumulated correct and incorrect runs were recorded for each session. The doorway designated as correct was changed each day throughout the training and testing period. On those days when the effects on learning of stimulation of the amygdalae or mamillary body were tested, the electrical brain stimulation was administered just prior to placing the rat in the runway. No detrimental effects on learning were associated with electrical stimulation of either brain structure. These findings are contrasted with our earlier study of hippocampal stimulation, which showed large deficits in learning ability.
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