| Autor: |
Kedia, Kailash R., Gibbons, Carol, Persky, Lester |
| Zdroj: |
The Journal of Urology; May 1981, Vol. 125 Issue: 5 p655-658, 4p |
| Abstrakt: |
Since October 1978, 25 patients with metastatic carcinoma of the bladder have been treated with cis-platinum, doxorubicin hydrochloride and cyclophosphamide. Patient selection for this protocol was relatively strict and included only patients who had measurable parameters. All 3 drugs (60mg./m.2cis-platinum, 40mg./m.2doxorubicin hydrochloride and 400mg./m.2cyclophosphamide) were given as a single dose every 4 weeks. Over-all, 19 of the 23 evaluable patients (82 per cent) responded to therapy. There were 5 complete drug-induced remissions and 14 partial remissions. Generally, the treatment was tolerated well and common toxic effects were myelosuppression, nausea, vomiting and alopecia. One patient died of septicemia as a result of agranulocytosis. These promising results seem to indicate the high degree of effectiveness of this combination chemotherapy against transitional cell carcinoma of the bladder. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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