| Autor: |
Oxford, John S, Lambkin, Robert, Gibb, Iain, Balasingam, Shobana, Chan, Charlotte, Catchpole, Andrew |
| Zdroj: |
Antiviral Chemistry & Chemotherapy; April 2005, Vol. 16 Issue: 2 p129-134, 6p |
| Abstrakt: |
A potent virucidal mixture containing amyl metacresol and dichlorobenzyl alcohol at low pH inactivated enveloped respiratory viruses influenza A, respiratory synctial virus (RSV) and severe acute respiratory syndrome coronavirus (SARS-CoV) but not viruses with icosahedral symmetry, such as adenoviruses or rhinoviruses. A titre of approximately 3.5 log10TCID50was reduced to below the level of detection within two minutes. Electron microscopy of purified influenza A virus showed extensive clumping and morphological changes in spike configuration after contact with the virucidal mixture, but no overt destruction of the viral membrane. We conclude that, formulated as a lozenge, the mixture could have significant effects in reducing the infectivity of certain infectious viruses in the throat and presumably in cough droplets, thus reducing, theoretically, opportunities for person-to-person transmission. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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