| Autor: |
Bülow, PM, Ibraheem, JJ, Paalzow, G, Tfelt-Hansen, P |
| Zdroj: |
Cephalalgia; June 1986, Vol. 6 Issue: 2 p107-111, 5p |
| Abstrakt: |
Plasma levels and the vasoconstrictive effect of 1 mg ergotamine tartrate given as tablets or suppositories were compared. In a crossover study, eight male volunteers received tablets or suppositories containing ergotamine in a drug combination (Anervan®) and, as a control, suppositories without ergotamine. Blood sampling and measurement of toe-arm systolic gradients with a strain-gauge technique were done for up to 6 h and again after 24 h and 48 h. Only 29 of 160 blood samples contained detectable (>0.1 mg/ml) amounts of ergotamine, and kinetic comparison could not be performed. Only ergotamine-containing suppositories caused a significant (p< 0.008) decrease in toe-arm systolic gradient which was significantly different (p< 0.003) from the effects of ergotamine tablets and control suppositories. Rectal ergotamine is thus more biologically active, for the factor used, than oral ergotamine. We suggest that a rectal dose of 1 mg ergotamine tartrate should be tried as the initial dose in the treatment of migraine attacks. |
| Databáze: |
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