| Autor: |
Santucci, Margherita, Cortelli, Pietro, Rossi, Paola Giovanardi, Baruzzi, Agostino, Sacquegna, Tommaso |
| Zdroj: |
Cephalalgia; September 1986, Vol. 6 Issue: 3 p155-157, 3p |
| Abstrakt: |
L-5HTP was tested versus placebo in a double-blind crossover study of 27 migraine children aged 6–12 years, who recorded their headaches in a headache diary for 1 month. Twenty-one patients subsequently started the trial. The mean daily dose of L-5HTP was 5 mg/kg body weight, and each treatment period with either L-5HTP or placebo lasted 12 weeks. In group A (L-5HTP—placebo; 10 patients) and group B (placebo—L-5HTP; 11 patients) both L-5HTP and placebo led to a significant reduction of the migraine index and frequency of migraine attacks during the 3rd month of each treatment period. However, we found a treatment x period interaction because the efficacy determinants decreased significantly during the first and the second treatment periods in both groups irrespective of the sequence of treatments. No differences were found between L-5HTP (first period of group A) and placebo (first period of group B). |
| Databáze: |
Supplemental Index |
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