| Autor: |
Flanigan, Robert C., Ellison, Mark F., Butler, Karen M., Gomella, Leonard G., McRoberts, J. William |
| Zdroj: |
The Journal of Urology; July 1986, Vol. 136 Issue: 1 p35-37, 3p |
| Abstrakt: |
There were 40 consecutive patients with recurrent or multiple superficial stage Ta or T1 transitional cell cancer assigned randomly to receive prophylactic thiotepa or mitomycin C intravesical chemotherapy. Patients received 8 weekly instillations followed by 22 monthly treatments of either 60mg. thiotepa or 40mg. mitomycin C. Of 25 patients randomized to receive mitomycin C 4 had recurrence in a total of 337 patient-months (1.19 per 100 patient-months), while disease recurred in 1 of 15 patients randomized to receive thiotepa who were followed for a total of 220 patient-months (0.45 per 100 patient-months). No significant difference in recurrrence rate was noted for either drug group (p equals 0.18). Toxicity requiring cessation of therapy was observed in 7 patients (28 per cent) on mitomycin C and none on thiotepa. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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