Cumulative Effects of Aging and Mechanical Ventilation on In VitroDiaphragm Function

Autor: Criswell, David S., Shanely, R. Andrew, Betters, Jenna J., McKenzie, Michael J., Sellman, Jeff E., Van Gammeren, Darin L., Powers, Scott K.
Zdroj: Chest; December 2003, Vol. 124 Issue: 6 p2302-2308, 7p
Abstrakt: Unloading the diaphragm, via mechanical ventilation (MV), results in significant diaphragmatic atrophy, contractile dysfunction, and oxidative stress in young adult animals. Since aging increases skeletal muscle susceptibility to atrophy and injury, we tested the hypothesis that MV-induced diaphragmatic contractile dysfunction would be exacerbated in aging rats.
Databáze: Supplemental Index