| Autor: |
Shammas, Fuad V., Ous, Sigurd, Fossa, Sophie D. |
| Zdroj: |
The Journal of Urology; March 1992, Vol. 147 Issue: 3 p630-632, 3p |
| Abstrakt: |
A total of 8 patients with advanced squamous cell carcinoma of the penis (Jackson stages III and IV) received chemotherapy with 100mg./m.2cisplatin intravenously on day 1 and a 24-hour infusion of 1,000mg./m.25-fluorouracil on days 1 to 5. Of the patients 2 (25%) achieved a partial response: 1 required a further operation and 1 required surgery with radiotherapy to achieve a complete response. These 2 patients were disease-free at 32+ and 57+ months. Nonresponders had a survival range of 2+ to 28 months after chemotherapy. Nausea and vomiting were the most frequent side effects of chemotherapy. Chemotherapy-related increase in serum creatinine occurred in 3 patients. Two patients had septicemia and 1 complained of tinnitus. Poor tolerability especially in the elderly was the main reason for discontinuing chemotherapy. The combination of cisplatin and 5-fluorour- acil may have a role in the management of advanced penile cancer together with surgery and radiotherapy. |
| Databáze: |
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