| Autor: |
Bouvet, J., Cariou, C., Valfort, W., Villard, S., Hilaire, F., Oberli, F., Cupillard, L., Guigal, P.M. |
| Zdroj: |
Vaccine Reports; December 2016, Vol. 6 Issue: 1 p23-28, 6p |
| Abstrakt: |
Efficacy of the Leptospiracomponents of EURICAN1®EURICAN is a registered trademark of Merial in France and elsewhere.1DAPPi-Lmulti, a canine combined vaccine, was tested after a primary course of two subcutaneous injections of one dose given 4weeks apart to puppies aged from seven to nine weeks. Challenges with three pathogenic serovars of Leptospiraspp. (Canicola, Icterohaemorrhagiae and Grippotyphosa) were carried out 14days (onset of immunity studies – OOIs) and 13–15months (duration of immunity studies – DOIs) after primary vaccination. During the four-week post challenge monitoring period, daily clinical observations were recorded, and blood (culture, biochemistry and haematology), urine (culture) and kidney (culture and histology) samples were collected regularly throughout the study or at necropsy. In OOIs, vaccination prevented mortality, clinical signs of the disease, infection, urinary excretion, renal carriage and renal lesions for all serovars. In DOIs, mortality, clinical signs and infection were less frequent in controls challenged with serovars Canicola and Grippotyphosa than in OOIs whereas they were absent or mild and transient in vaccinated dogs. Urinary excretion, renal carriage and renal lesions were at least significantly reduced in vaccinated dogs compared to controls for all serovars. |
| Databáze: |
Supplemental Index |
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