| Abstrakt: |
Aim— The aim of this study was to investigate iron status and its relationships with lipid peroxidation in patients with acute myocardial infarction (MI).Methods— The study included 30 male patients aged between 32 and 73 years (mean 55 ± 6) with acute MI.We measured the levels of plasma iron, transferrin (TF), ferritin (FER), ceruloplasmin (CER), cardiac enzymes, and erythrocyte malondialdehyde (e-MDA) in patients with acute MI on the admission and 1st, 3rd, 5th, 7th, 15th, 45thpost MI day and investigated the variations of these parameters in acute MI.Results— The e-MDA level started to increase on the admission day and showed a peak value on the post MI 1stday (88 ± 23 and 98 ± 26 nmol/g Hb, respectively). Afterwards, the e-MDA level minimally changed until post MI 45thday, which showed a minimum level (57 ± 13 nmol/g Hb) (p < 0.05). In addition, the iron concentration of serum reached its maximum level on the 1stpost MI day (99 ± 30 mg/dl, p < 0.05) and relatively decreased after the 3rdday. Courses of MDA and iron levels were similar. The FER level started to increase from the admission day of the patients (230 ± 375 mg/dl), showed a mean peak value on the 3rdday (296 ± 568 mg/dl) and decreased to a minimum level on the 45thday (121 ± 85 mg/dl) (p <0.05). Contrarily, the TF level started to decrease on the 1stday (221 ± 44 mg/dl), decreased minimum level on the 3rdday (211 ± 37 mg/dl) and continued approximately the same level until the 45thday (244 ± 45 mg/dl) (p < 0.05). The CER level started to increase from the first day of admission of the patients (43 ± 12 mg/dl), reached a maximum level on the 7thday (59 ± 12 mg/dl) and similar levels were observed until the 15thday. On the 45thday, the CER level was higher than on the first day (52 ± 13 mg/dl) (p < 0.05).Conclusion— There was an association of higher iron status with increased lipid peroxidation in patients with myocardial infarction. |
