A Clinical Strain of Escherichia coli Possessing CMY-2 Plasmid-Mediated Amp C β-Lactamase: An Emerging Concern in Pediatrics?

Autor: Hoyen, Claudia M., Hujer, Andrea M., Hujer, Kristine M., Marshall, Steven H., Carias, Lenore, Toltzis, Philip, Rice, Louis B., Bonomo, Robert A.
Zdroj: Microbial Drug Resistance: Mechanism, Epidemiology, and Disease; December 01, 2002, Vol. 8 Issue: 4 p329-333, 5p
Abstrakt: A 5-year-old child was colonized by an isolate of Escherichia coli that transferred resistance to third-generation cephalosporins and cefoxitin. This resistance phenotype was encoded on a >75-kb plasmid pLRM 22. The transferable plasmid contained both blaCMY-2 and blaTEM-1b. Increasing reports of CMY-2 β-lactamase in clinical isolates in children raise concerns about the empiric use of third-generation cephalosporins in this patient group.
Databáze: Supplemental Index