Autor: |
Schnell, Barbara, Strauss, Ulrike T, Verdino, Petra, Faber, Kurt, Kappe, C.Oliver |
Zdroj: |
Tetrahedron: Asymmetry; April 2000, Vol. 11 Issue: 7 p1449-1453, 5p |
Abstrakt: |
A practical and short synthesis of the enantiomerically pure dihydropyrimidone antihypertensive agent (R)-SQ 32926 has been developed. The key step in the synthesis is the enzymatic resolution of an N3-acetoxymethyl-activated dihydropyrimidone precursor by Thermomyces lanuginosuslipase. The absolute configuration of (R)-SQ 32926 was confirmed by circular dichroism spectroscopy. |
Databáze: |
Supplemental Index |
Externí odkaz: |
|