Synthesis of enantiomerically pure 4-aryl-3,4-dihydropyrimidin-2(1H)-ones via enzymatic resolution: preparation of the antihypertensive agent (R)-SQ 32926†Synthesis and reactions of Biginelli compounds, part 20; for part 19, see: Kappe, C. O.; Shishkin, O. V.; Uray, G.; Verdino, P. Tetrahedron2000, 56, 1859–1862.†

Autor: Schnell, Barbara, Strauss, Ulrike T, Verdino, Petra, Faber, Kurt, Kappe, C.Oliver
Zdroj: Tetrahedron: Asymmetry; April 2000, Vol. 11 Issue: 7 p1449-1453, 5p
Abstrakt: A practical and short synthesis of the enantiomerically pure dihydropyrimidone antihypertensive agent (R)-SQ 32926 has been developed. The key step in the synthesis is the enzymatic resolution of an N3-acetoxymethyl-activated dihydropyrimidone precursor by Thermomyces lanuginosuslipase. The absolute configuration of (R)-SQ 32926 was confirmed by circular dichroism spectroscopy.
Databáze: Supplemental Index