| Autor: |
Rao, Pemmaraju N., Wang, Zhiqiang, Cessac, James W., Rosenberg, Rachel S., Jenkins, David J.A., Diamandis, Eleftherios P. |
| Zdroj: |
Steroids; October 1998, Vol. 63 Issue: 10 p523-530, 8p |
| Abstrakt: |
The syntheses of three 11β-aryl-19-norpregna-4,9-dien-3-one derivatives with 17-spirolactone and 17β-hydroxy-17α-cyanoethyl substitutions are described. The progesterone agonist/antagonist activities of the new compounds are investigated using a recently developed tissue culture system that relies on the progesterone agonist up-regulation of the prostate-specific antigen (PSA) gene in female breast tumor cell lines. Two of the newly synthesized compounds exhibit mixed agonistic/antagonistic progestational activity. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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