Omega-3 polyunsaturated fatty acids improve the antioxidative defense in rat astrocytes viaan Nrf2-dependent mechanism

Autor: Zgórzyńska, Emilia, Dziedzic, Barbara, Gorzkiewicz, Anna, Stulczewski, Dawid, Bielawska, Katarzyna, Su, Kuan-Pin, Walczewska, Anna
Zdroj: Pharmacological Reports; October 2017, Vol. 69 Issue: 5 p935-942, 8p
Abstrakt: Neuronal tolerance to hypoxia and nutrient defficiency highly depends on GSH levels and antioxidant enzyme activity in astrocytes. Omega-3 polyunsaturated fatty acids (ω-3PUFA) enhance antioxidant defence in different cells. The aim of present study was to investigate if ω-3PUFA improve antioxidant status in astrocytes.
Databáze: Supplemental Index