| Autor: |
Hotta, Kikuko, Kuwajima, Masamichi, Ono, Akira, Nakajima, Hiromu, Shingu, Ryosuke, Miyagawa, Jun-ichiro, Namba, Mitsuyoshi, Hanafusa, Toshiaki, Noguchi, Tamio, Kono, Norio, Matsuzawa, Yuji |
| Zdroj: |
Biochimica et Biophysica Acta. General Subjects; February 1996, Vol. 1289 Issue: 1 p145-149, 5p |
| Abstrakt: |
Expression of key regulatory enzymes involved in glucose metabolism was studied in the livers of Otsuka Long-Evans Tokushima fatty (OLETF) rats, a model of non-insulin dependent diabetes mellitus. The activity and mRNA levels of glucokinase and L-type pyruvate kinase was increased in the liver of OLETF rats compared with control rats. There was no such remarkable change in liver-type phosphofructokinase. The activities of glucose-6-phosphatase and fructose-1,6-bisphosphatase also increased despite high plasma levels of glucose and insulin. The activity of phosphoenolpyruvate carboxykinase did not show any significant change. The mRNA levels for fructose-1,6-bisphophatase, and phosphoenolpyruvate carboxykinase exhibited no marked changes. These results suggest that the expression of glucose-6-phosphatase and fructose-1,6-bisphophatase is disordered in OLETF rats. |
| Databáze: |
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